If the Donald Trump administration argues that multilateralism is in any way an infringement of sovereignty as a motto to the flawed jargon of "Make America Great Again", then the administration will only succeed in further isolating the United States (US) at a crucial juncture when international cooperation is needed to further human development.
Multilateralism and not imperialism or nationalism, is what has brought great wealth and power to the US over the years. Yet, instead of continuing the developmental alliance with other nations toward the general good of Planet Earth, the Trump administration as the president might today claim at the United Nations General Assembly (UNGA), could deepen the Republic's growing isolation by summoning a larger break in cooperation with European and other allies.
Multilateralism is good. It is good economics and governance. It does not infringe upon sovereignty, but certainly enhances it for allowing for a healthy exchange of views, policies and works, to further the existence of the human species.
While isolation might appear attractive to nationalists who only see their own backyards and not the wider forests, in the long run, isolationists policies could lead to the death of a nation state since it would become contained within a limited scope of influence, thus unable to grow as a healthy organism.
Therefore, for the good of the world's stability, security and environment, as well as that of the Republic, isolationism must be deemed as a self-infected policy to state-death and be condemned. Multilateralism should be promoted and embraced as a means to the greater wealth and health of nation states.